Dual inhibition of vacuolar ATPase and TMPRSS2 is required for complete blockade of SARS-CoV-2 entry into cells
S. Icho, E. Rujas, K. Muthuraman, J. Tam, H. Liang, S. Harms, M. Liao, D. Falzarano, J.-P. Julien, R. Melnyk
This study identifies bafilomycin A1 as a potent inhibitor of SARS-CoV-2 entry via the endosomal route and shows synergy with TMPRSS2 inhibitors.
bioRxiv · Mar 11, 2022Cell Biology