J. Tam

Metabolic Reprogramming Driven by Ant2 -Targeting Augments T-Cell Function and Anti-Tumor Immunity

This study shows that Ant2 deficiency enhances T-cell function and anti-tumor immunity by altering mitochondrial metabolism and metabolic reprogramming.

Antimicrobial blue light-bathing therapy for wound infection control

This study introduces a low-irradiance blue light therapy for wound infections, showing it effectively reduces bioburden while being safer than high-irradiance methods.

Atomically accurate de novo design of antibodies with RFdiffusion

This paper designs antibodies de novo with atomic precision using RFdiffusion and yeast display, validated by cryo-EM and biophysical methods.

Keywords to success: a practical guide to maximise the visibility and impact of academic papers

The paper provides evidence-based recommendations to improve the discoverability and impact of academic papers through optimized use of keywords and abstract structure.

Increased susceptibility to ischemia causes exacerbated response to microinjuries in the cirrhotic liver

The paper examines the liver's response to microinjuries in healthy and cirrhotic rats, finding that cirrhotic livers show increased susceptibility to ischemia and exacerbated cell death.

Analysis of culture and RNA isolation methods for precision-cut liver slices from cirrhotic rats

This study evaluates culture and RNA isolation methods for cirrhotic precision-cut liver slices, finding that insulin and dexamethasone improve albumin production and gene expression.

Inhibition of somatostatin enhances the long-term metabolic outcomes of sleeve gastrectomy in mice

This study shows that inhibiting somatostatin signaling improves and sustains metabolic benefits after sleeve gastrectomy in mice.

Iterative transcription factor screening enables rapid generation of microglia-like cells from human iPSC

This study uses iterative transcription factor screening to generate microglia-like cells from human iPSCs, identifying a combination of TFs that efficiently differentiate iPSCs into microglia-like cells within 4 days.

Tauroursodeoxycholic acid inhibits Clostridioides difficile toxin induced apoptosis

This study shows that taurine-conjugated ursodeoxycholic acid (TUDCA) inhibits C. difficile toxin-induced apoptosis in Caco-2 cells, while unconjugated UDCA does not, highlighting the importance of bile acid conjugation in CDI therapy.

Dual inhibition of vacuolar ATPase and TMPRSS2 is required for complete blockade of SARS-CoV-2 entry into cells

This study identifies bafilomycin A1 as a potent inhibitor of SARS-CoV-2 entry via the endosomal route and shows synergy with TMPRSS2 inhibitors.

Protective and aggressive bacterial subsets and metabolites modify hepatobiliary inflammation and fibrosis in PSC.

This study identifies protective and aggressive bacterial subsets and metabolites in PSC patients and mice, showing their impact on hepatobiliary inflammation and fibrosis.

Transcriptomic analysis of pathways associated with alpha(v) integrin-related non-canonical autophagy in human B cells

The paper investigates the role of non-canonical autophagy in human B cells, showing it is induced in specific sub-populations and influences activation pathways.

Peripheral sgp130-mediated trans-signaling blockade induces obesity and insulin resistance in mice via PPARα suppression

This study shows that blocking peripheral sgp130-mediated trans-signaling in mice causes obesity and insulin resistance by suppressing PPARα.

TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin

This study shows GIV/Girdin dampens TLR4-mediated inflammatory responses in macrophages by inhibiting receptor dimerization and downstream signaling.

Electrostatic Fields Have Strong Repellency Effects Against Culex pipiens

This study demonstrates that high-voltage electrostatic fields can repel mosquitoes effectively, offering a safe, long-lasting alternative to DEET with full-body protection.