Author

D. Falzarano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 7 Organism:human· 5 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

V. Gerdts· 4 shared J. Lew· 3 shared A. Kroeker· 2 shared C. McCormick· 2 shared E. S. Pringle· 2 shared J. Kindrachuk· 2 shared M. Francis· 2 shared S. Harms· 2 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

V. Gerdts

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Dual inhibition of coronavirus Mpro and PLpro enzymes by phenothiazines and their antiviral activity

K. L. Forrestall, E. S. Pringle, D. Sands, B. Duguay, B. Farewell, T. Woldemariam, D. Falzarano, I. R. Pottie, C. McCormick, S. Darvesh

This paper identifies a phenothiazine urea derivative that inhibits both SARS-CoV-2 Mpro and PLpro proteases and shows broad antiviral activity against multiple human coronaviruses.

bioRxiv · Sep 11, 2023 · PreprintMicrobiology

An S1 subunit vaccine and combination adjuvant (COVAC-1) elicits robust protection against SARS-CoV-2 challenge in African green monkeys

L. Garnett, K. Tran, M. Chan, K. Tierney, Z. Schiffman, J. Audet, J. Lew, C. Meilleur, M. Chan, K. Manguiat, N. Tailor, R. Vendramelli, Y. Deschambault, G. Beaudoin-Bussieres, C. Bourassa, , D. Falzarano

COVAC-1, an S1 subunit vaccine with adjuvant, protects African green monkeys from SARS-CoV-2 challenge by reducing viral load and pathology in the respiratory tract.

bioRxiv · Jun 16, 2022 · PreprintMicrobiology

Dual inhibition of vacuolar ATPase and TMPRSS2 is required for complete blockade of SARS-CoV-2 entry into cells

S. Icho, E. Rujas, K. Muthuraman, J. Tam, H. Liang, S. Harms, M. Liao, D. Falzarano, J.-P. Julien, R. Melnyk

This study identifies bafilomycin A1 as a potent inhibitor of SARS-CoV-2 entry via the endosomal route and shows synergy with TMPRSS2 inhibitors.

bioRxiv · Mar 11, 2022Cell Biology

Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions

E. S. Pringle, B. A. Duguay, M. P. Bui-Marinos, R. P. Mulloy, S. L. Landreth, K. S. Desireddy, S. M. Dolliver, S. Ying, T. Caddell, P. D. Slaine, S. L. Bearne, D. Falzarano, J. Corcoran, D. A. Khaperskyy, C. McCormick

This paper shows that thiopurines inhibit coronavirus replication by disrupting Spike protein processing and incorporation into virions.

bioRxiv · Mar 10, 2022Microbiology

Immunogenicity of convalescent and vaccinated sera against clinical isolates of ancestral SARS-CoV-2, beta, delta, and omicron variants

A. Banerjee, J. Lew, A. Kroeker, K. Baid, P. Aftanas, K. Nirmalarajah, F. Maguire, R. Kozak, R. McDonald, A. Lang, V. Gerdts, S. E. Straus, L. Gilbert, A. X. Li, M. Mozafarihasjin, , D. Falzarano

The paper assesses neutralizing antibody responses of convalescent and vaccinated sera against SARS-CoV-2 ancestral, beta, delta, and omicron variants.

bioRxiv · Jan 13, 2022Immunology

SARS-CoV-2 infection in the Syrian hamster model causes inflammation as well as type I interferon dysregulation in both respiratory and non-respiratory tissues including the heart and kidney

M. Francis, U. Goncin, A. Kroeker, C. Swan, R. Ralph, Y. Lu, A. Etzioni, D. Falzarano, V. Gerdts, S. Machtaler, J. Kindrachuk, A. A. Kelvin

This study shows SARS-CoV-2 infection in Syrian hamsters causes inflammation and type I interferon suppression in multiple organs, including the heart and kidney, similar to human COVID-19 symptoms.

bioRxiv · Apr 7, 2021Microbiology

Male sex and age biases viral burden, viral shedding, and type 1 and 2 interferon responses during SARS-CoV-2 infection in ferrets

M. Francis, B. Richardson, M. McNeil, M. Rioux, M. Foley, A. Ge, R. Pechous, J. Kindrachuk, C. Cameron, C. Richardson, J. Lew, M. Cameron, V. Gerdts, D. Falzarano, A. A. A. Kelvin

This study shows that male sex and age in ferrets affect viral burden, shedding, and interferon responses during SARS-CoV-2 infection, with older males showing delayed antiviral responses.

bioRxiv · Jan 12, 2021Microbiology

Spike protein disulfide disruption as a potential treatment for SARS-CoV-2

A. M. Grishin, N. V. Dolgova, S. Harms, I. J. Pickering, G. N. George, D. Falzarano, M. Cygler

This paper shows that reducing disulfide bonds in the SARS-CoV-2 Spike protein inhibits viral entry and replication, suggesting a potential antiviral treatment.

bioRxiv · Jan 2, 2021 · PreprintMicrobiology