M. Liao

Structural basis of respiratory complexes adaptation to cold temperatures

This study identifies a cold-induced conformation of respiratory complex CI:III2 using cryo-EM and simulations, revealing structural changes that enhance electron transfer efficiency in cold environments.

The crystal and cryo-EM structures of PLCγ2 reveal dynamic inter-domain recognitions in autoinhibition

The paper determines crystal and cryo-EM structures of PLCγ2 in autoinhibited states and bound to FGFR1 kinase domain, revealing dynamic inter-domain interactions in autoinhibition.

Coronavirus endoribonuclease nsp15 induces host cellular protein synthesis shutoff

This study shows that coronavirus nsp15 inhibits host protein synthesis and targets host mRNA, with EndoU activity essential for these effects and virus replication.

Topology recapitulates ontogeny of dendritic arbors

The paper investigates whether dendritic arbors exhibit topological properties reflecting their growth and function, finding a power-law tip-support distribution across many neurons.

The structure, catalytic mechanism, and inhibitor identification of phosphatidylinositol remodeling MBOAT7

This study determines the structure of MBOAT7, models its catalytic mechanism, and identifies potential inhibitors for therapeutic development.

Integrated analysis of intestinal microbiota and metabolomic reveals that decapod iridescent virus 1 (DIV1) infection induces secondary bacterial infection and metabolic reprogramming in Marsupenaeus japonicus

This study investigates how DIV1 infection in Marsupenaeus japonicus affects intestinal microbiota, metabolomics, and immune response, revealing secondary bacterial infection and metabolic reprogramming.

Deeply conserved super-enhancers maintain stem cell pluripotency in placental mammals

The paper identifies three deeply conserved super-enhancers in placental mammals that are essential for maintaining stem cell pluripotency.

Dual inhibition of vacuolar ATPase and TMPRSS2 is required for complete blockade of SARS-CoV-2 entry into cells

This study identifies bafilomycin A1 as a potent inhibitor of SARS-CoV-2 entry via the endosomal route and shows synergy with TMPRSS2 inhibitors.

Engineered high-density lipoprotein particles that chaperone bioactive lipid mediators to combat endothelial dysfunction and thromboinflammation

This paper constructs engineered HDL-like particles that chaperone bioactive lipids to reduce inflammation and endothelial dysfunction.

Obesity associated with attenuated tissue immune cell responses in COVID-19

The paper finds that obesity is associated with reduced immune and inflammatory responses in COVID-19 patients, including lower expression of IFN and IFNγ response genes in lung and blood cells.

Counting fluorescently labeled proteins in tissues in the spinning disk microscope using single-molecule calibrations

The paper develops a calibration technique for spinning-disk confocal microscopy to count fluorescent proteins in tissues, enabling accurate quantification of molecular numbers and concentrations.

Sub-3 Angstrom cryo-EM structure of RNA enabled by engineered homomeric self-assembly

This paper introduces a method to improve cryo-EM analysis of RNA structures by engineering kissing-loop sequences for homomeric assembly, achieving high-resolution reconstructions of RNA molecules.

Distinct allosteric mechanisms of first-generation MsbA inhibitors

This study investigates how two first-generation MsbA inhibitors, TBT1 and G247, induce opposite allosteric effects by binding to distinct sites in the transmembrane domains.

An enveloped virus-like particle vaccine expressing a stabilized prefusion form of the SARS-CoV-2 spike protein elicits potent immunity after a single dose.

This paper evaluates an enveloped virus-like particle vaccine, VBI-2902a, which elicits strong immunity against SARS-CoV-2 after a single dose in mice and hamsters.

Population genomics of Salmonella enterica serovar Weltevreden ST365, an emerging predominant causative agent of diarrheal disease

This study identifies ST365 as the predominant causative agent of S. Weltevreden diarrhea outbreaks globally and discovers a novel virulence plasmid associated with its pathogenicity.

Mechanism of LolCDE as a molecular extruder of bacterial triacylated lipoproteins

This study determines the cryo-EM structures of LolCDE and reveals its mechanism for extracting triacylated lipoproteins from the cytoplasmic membrane.

Chicken peripheral blood lymphocyte response to ALV-J infection assessed by single-cell RNA sequencing

This study uses single-cell RNA sequencing to analyze chicken peripheral blood lymphocytes infected with ALV-J, identifying T cell subsets and their molecular responses to infection.

Collagen induced inflammations

This paper describes a protocol for inducing collagen-induced arthritis (CIA) in mice using bovine collagen type II and Freund's adjuvants, and reports associated enteritis and arthritis outcomes.

Long-term survival of salmon-attached SARS-CoV-2 at 4 degree as a potential source of transmission in seafood markets

This study shows that SARS-CoV-2 attached to salmon can remain infectious for over a week at 4°C, indicating a potential transmission risk in seafood markets.

Histone demethylase complexes KDM3A and KDM3B cooperate with OCT4/SOX2 to construct pluripotency gene regulatory network

The paper shows that KDM3A and KDM3B, along with OCT4/SOX2, regulate H3K9 methylation to maintain pluripotency in porcine-induced pluripotent stem cells.

Proto-sex locus in large yellow croaker provides insights into early evolution of the sex chromosome

The paper identifies a proto-sex locus in large yellow croaker, showing reduced recombination and dmrt1 expression in testis development and shared functional links between genetic sex determination and environmental sex reversal.

The Narrowing of Dendrite Branches across Nodes follows a well-defined Scaling Law

The paper tests scaling laws for dendrite diameters in Drosophila neurons and discovers a new law based on cross-sectional area and minimum diameter.

Multiple splitting of droplets using multi-furcating microfluidic channels

This paper designs multi-furcating microfluidic channels for efficient droplet splitting and investigates splitting regimes and breakup mechanisms.

Structure and function of a 9.6 megadalton bacterial iron storage compartment

This study characterizes a bacterial iron storage compartment using structural methods, revealing its large iron storage capacity and functional mechanism.

Cryo-electron microscopy structure of the lipid droplet-formation protein seipin

The paper reports the cryo-EM structure of D. melanogaster seipin and proposes a model for its role in lipid droplet formation.

Structure and function of accessory Sec proteins involved in the adhesin export pathway of Streptococcus gordonii

This study investigates the sequential O-glycosylation of an adhesin in Streptococcus gordonii and its interaction with accessory Sec proteins for export.