Cell BiologybioRxivPreprint
Adaptation to ex vivo culture drives human haematopoietic stem cell loss of repopulation capacity in a cell cycle independent manner
C. S. Johnson, K. Sham, S. Belluschi…·E. Laurenti
This study shows that human LT-HSC loss of repopulation capacity during ex vivo culture occurs rapidly after adaptation, independent of cell cycle progression.