Cell BiologybioRxivPreprint
SPRTN protease and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability
B. Vaz, A. Ruggiano, M. Popovic…·K. Ramadan
This study identifies SUMO-1 modification of DNA-protein crosslinks (DPCs) as a mechanism that promotes SPRTN proteolysis over homologous recombination, preventing genomic instability.
DOI 10.1101/2020.02.14.949289