Radiation Exposure of the Base of the Heart Accelerates Coronary Atherosclerosis
P. R. Nepali, M. Mathieu, S. Kitz, C. Nakauchi, K. Gabriels, J. Russell, S. Monette, J. A. te Poele, S. Heeneman, A. Rimner, Y. Qiu, I. J. Kurland, F. A. Stewart, E. A. Jaimes, A. Haimovitz-Friedman
This study shows that radiation to the base of the heart accelerates coronary atherosclerosis in mice, while apex irradiation does not, suggesting targeted protection of the heart base may reduce radiation-induced atherosclerosis in patients.
bioRxiv · Apr 8, 2021 · PreprintCancer Biology