The phenuivirus Toscana virus makes an atypical use of vacuolar acidity to enter host cells
J. Koch, Q. Xin, M. Obr, A. Schaefer, N. Rolfs, H. A. Anagho, A. Kudulyte, L. Woltereck, S. Kummer, J. Campos, Z. M. Uckeley, L. Bell-Sakyi, H.-G. Kraeusslich, F. K. Schur, C. Acuna, P.-Y. Lozach
This study identifies Toscana virus as a late-penetrating virus that uses vacuolar acidity for entry, with an optimal fusion pH of 5.5 and infectious particles remaining viable below this threshold.
bioRxiv · Mar 6, 2023Microbiology