W. Wan

Engineered Migrasomes: Harnessing Core Migrasome Machinery and Hypotonic Shock to Develop a Robust and Thermally Stable Vaccine Platform

This study engineers migrasome-like vesicles (eMigrasomes) using hypotonic shock to create a stable, thermally robust vaccine platform that elicits strong immune responses.

Utility of long-read sequencing for All of Us

The paper compares short-read and long-read sequencing in the All of Us initiative, finding HiFi reads provide the most accurate variant calling and presents a cloud-based pipeline for long-read analysis.

Intracellular Ebola Virus nucleocapsid assembly revealed by in situ cryo-electron tomography.

This study uses cryo-electron tomography to reveal the structure of the intracellular Ebola virus nucleocapsid, identifying a new outer layer of NP complexed with VP35 and conserved assembly interfaces.

Improved mammalian retromer cryo-EM structures reveal a new assembly interface

The paper improves mammalian retromer cryo-EM structures, revealing a new assembly interface between VPS26A and VPS35 N-termini.

In situ architecture of the ciliary base reveals the stepwise assembly of IFT trains

The paper visualizes the native structure of the ciliary transition zone and the stepwise assembly of IFT trains in Chlamydomonas cells.

Novel cryo-electron tomography structure of Arp2/3 complex in cells reveals mechanisms of branch formation

The paper presents a cryo-electron tomography structure of the Arp2/3 complex in cells, revealing new insights into branch formation mechanisms.

The native structure of the full-length, assembled influenza A virus matrix protein, M1.

This study determines the structure of assembled influenza A virus matrix protein M1 and reveals how it oligomerizes to mediate virion assembly and disassembly.

Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers

The paper determines the structure of VP40 matrix layers in Ebola and Marburg virus-like particles, revealing they are locally ordered assemblies of VP40 dimers forming 2D lattices.

Cardiac myocytes respond differentially and synergistically to matrix stiffness and topography

This study shows that cardiac myocytes respond differently to matrix stiffness and topography, with synergistic effects on their phenotype, highlighting that alignment alone does not indicate cellular health.