X. Xiong

This study shows that adding thiols to auranofin restores its anticancer activity by modulating albumin-gold binding and enhancing therapeutic efficacy.

The paper identifies a dsRNA Totiviridae virus in two diatom strains, shows it can be removed to create virus-free lines, and suggests it causes latent infection rather than lytic infection.

This study determines cryoEM structures of ZIKV NS1 with two groups of antibodies, revealing distinct epitope recognition mechanisms and protective efficacy differences.

The paper identifies public antibodies using VL6-57 light chains that target a conserved epitope on SARS-CoV-2 spike protein, showing how Omicron variants evolved to escape these antibodies.

This study identifies chlorhexidine and its derivative CM002 as clock activators with anti-adipogenic properties, showing they inhibit adipogenesis via Wnt pathway activation.

This study shows that cross-feeding and spatial structure in bacterial communities can lead to increased antibiotic persistence in E. coli through 'dynamical loss of access to nutrient'.

The paper develops a high-throughput imaging platform to assess the functional impact of missense variants on protein localization, finding that mislocalization is common in pathogenic variants.

This study introduces disulfides into SARS-CoV-1 spike protein to stabilize locked conformations, revealing conserved structural features with SARS-CoV-2.

This study identifies Cry2's role in adipogenesis through its interaction with Per2, showing that repression of Wnt signaling promotes adipocyte development.

This study identifies RAY1216, a slow-tight SARS-CoV-2 Mpro inhibitor with improved pharmacokinetics and antiviral activity compared to PF-07321332, currently in phase III clinical trials.

This study shows Nobiletin suppresses adipogenesis by enhancing the circadian clock and activating Wnt signaling, leading to reduced fat mass and body weight in mice.

The paper identifies the T813S mutation in the S2 subunit of SARS-CoV Spike protein enhances fusogenicity by improving TMPRSS2 cleavage, increasing viral replication.

A protease inhibitor from kumquat enhances freezing tolerance by stabilizing proteins through inhibition of non-specific protease degradation.

This study engineers a SARS-CoV-2 spike protein with a disulfide bond to stabilize the locked conformation, revealing structural dynamics and the role of domain D in conformational changes and viral fitness.

This study shows that actin cytoskeleton signaling via MRTF/SRF modulates circadian clock entrainment by responding to extracellular matrix cues.

This study identifies a circadian clock control of MRTF-SRF signaling that suppresses beige adipocyte thermogenic recruitment and maintains metabolic homeostasis.

This study shows NAC1 suppresses regulatory T cell-mediated tolerance by deacetylating and destabilizing FoxP3, leading to autoimmunity, and suggests targeting NAC1 could treat autoimmune disorders.

This study identifies THEMIS as a substrate of SHP1 and shows it has phosphorylation-dependent and -independent roles in T cell development.

This study shows metformin reduces TNF-α production in B cells of PCOS patients and mice by inhibiting mTOR and altering metabolism.

ToxoNet constructs a high-confidence protein-protein interaction map for Toxoplasma gondii, identifying novel virulence factors involved in host cell invasion.

This study investigates how Toxoplasma gondii infection affects dopamine-sensitive behaviors and gene expression in mice, revealing interactions between infection and cocaine exposure that may contribute to neuropsychiatric disorders.

This study identifies an integrin-actin cytoskeleton-MRTF/SRF signaling cascade that modulates circadian clock properties by directly regulating core clock genes.

This study shows invasive earthworms alter soil microbiomes and shift nitrogen cycling from nitrification to denitrification in hardwood forests.

This study evaluates closed-state SARS-CoV-2 spike protein immunization in mice, finding it induces potent neutralizing antibodies and T-cell responses, with unique binding properties compared to standard S protein constructs.

This study identifies a monoclonal antibody that broadly neutralizes multiple beta-coronaviruses by targeting a conserved epitope, providing a structural basis for designing pan-coronavirus vaccines.

This study uses cryo-electron microscopy to determine the structure, conformational flexibility, and distribution of SARS-CoV-2 spike protein trimers on intact virions.

This study determines the structure of assembled influenza A virus matrix protein M1 and reveals how it oligomerizes to mediate virion assembly and disassembly.

This paper designs a thermostable, closed SARS-CoV-2 spike protein trimer that remains in the pre-fusion state and can be used in serological assays.

NAD+ supplementation enhances T cell activation and tumor-killing capacity in immunotherapies.

This paper identifies a novel protein complex in Arabidopsis that regulates ROS1-mediated active DNA demethylation and targets ROS1 to specific genomic regions.