O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Likely Contribute to the Mutational Trajectory in Variants of Concern
E. Gonzalez-Rodriguez, M. Zol-Hanlon, G. Bineva-Todd, A. Marchesi, M. Skehel, K. Mahoney, C. Roustan, A. Borg, L. Di Vagno, S. Kjaer, A. G. Wrobel, D. J. Benton, P. Nawrath, S. L. Flitsch, D. Joshi, , B. Schumann
This paper shows that O-linked sialoglycans affect SARS-CoV-2 spike proteolysis by furin and TMPRSS2, and may drive mutations in variants of concern.
bioRxiv · Sep 15, 2022Cell Biology