A. Borg

O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Likely Contribute to the Mutational Trajectory in Variants of Concern

This paper shows that O-linked sialoglycans affect SARS-CoV-2 spike proteolysis by furin and TMPRSS2, and may drive mutations in variants of concern.

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp13 Helicase

This study identifies small molecule inhibitors of SARS-CoV-2 nsp13 helicase by screening a chemical library and validates their antiviral efficacy in cell culture.

A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing

The paper reports crystal and cryo-EM structures of zebrafish RET revealing conformational flexibility and strict geometric spacing in ligand-co-receptor recognition.

Spatial Deconvolution of HER2-positive Breast Tumors Reveals Novel Intercellular Relationships

This study uses spatial transcriptomics to analyze HER2-positive breast tumors, revealing novel intercellular relationships and developing a model for tertiary lymphoid structures across tissues.

The Mutational Landscape of the SCAN-B Real-World Primary Breast Cancer Transcriptome

The paper develops a pipeline to detect mutations from RNA-seq data in breast cancer and shows it can identify mutations in key genes and pathways in 86.8% of tumors.

Multidimensional transcriptomics provides detailed information about immune cell distribution and identity in HER2+ breast tumors

This study uses multidimensional transcriptomics to analyze immune cell distribution and identity in HER2+ breast tumors, revealing spatial heterogeneity and interpatient differences in immune infiltration.

Free ISG15 as a dimer generates IL-1β-producing CD8α+ dendritic cells at the site of infection

The paper shows free ISG15 dimers enhance IL-1β production by CD8+ dendritic cells during Toxoplasma infection, linking ISG15 to cytokine responses.