C. Roustan

Preservation of memory B cell homeostasis in an individual producing broadly neutralising antibodies against HIV-1

The paper isolates a broadly neutralizing HIV-1 antibody from an untreated HIV-1 patient and shows memory B cells remain functional despite viral infection.

O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Likely Contribute to the Mutational Trajectory in Variants of Concern

This paper shows that O-linked sialoglycans affect SARS-CoV-2 spike proteolysis by furin and TMPRSS2, and may drive mutations in variants of concern.

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp13 Helicase

This study identifies small molecule inhibitors of SARS-CoV-2 nsp13 helicase by screening a chemical library and validates their antiviral efficacy in cell culture.

Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV

This study examines SARS-CoV-2-specific immune responses in people living with HIV on ART, finding comparable antibody and T cell responses to HIV-negative individuals, with T cell magnitude linked to CD4 T cell pool size and CD4:CD8 ratio.

The impact of Spike mutations on SARS-CoV-2 neutralization

This study evaluates how Spike mutations in SARS-CoV-2 variants affect neutralization by monoclonal and polyclonal antibodies, showing reduced activity in some cases.

Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans

The paper identifies pre-existing and de novo humoral immunity to SARS-CoV-2 in humans, showing that uninfected individuals have SARS-CoV-2 S-reactive antibodies, particularly in children, and that infection leads to higher antibody titres targeting multiple subunits.