S. Kjaer

Mechanism of chaperone coordination during cotranslational protein folding in bacteria

The paper investigates how chaperones coordinate during cotranslational protein folding in bacteria, showing they create a protected space for maturation without destabilizing intermediates.

Evolution and inhibition of the FIKK effector kinase family in P. falciparum

This study investigates the evolution and inhibition of FIKK kinases in P. falciparum, showing they can be inhibited by a single compound.

O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Likely Contribute to the Mutational Trajectory in Variants of Concern

This paper shows that O-linked sialoglycans affect SARS-CoV-2 spike proteolysis by furin and TMPRSS2, and may drive mutations in variants of concern.

Broad human and animal coronavirus neutralisation by SARS-CoV-2 S2-targeted vaccination

This study shows that SARS-CoV-2 S2-targeted vaccination induces broad neutralizing antibodies against multiple coronaviruses and provides better protection than homologous boosting.

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp13 Helicase

This study identifies small molecule inhibitors of SARS-CoV-2 nsp13 helicase by screening a chemical library and validates their antiviral efficacy in cell culture.

Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains

This study compares antibody cross-reactivity between SARS-CoV-2 B.1.1.7 and parental strains, finding reduced recognition and neutralization of older variants after B.1.1.7 infection.

Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization

This study shows that SGS mutations in SKI prevent its binding to phosphorylated SMAD2/3, leading to SKI stabilization and reduced TGF-β responses.

MICAL2 acts through Arp3B isoform-specific Arp2/3 complexes to destabilize branched actin networks

The paper shows MICAL2 regulates Arp3B-specific Arp2/3 complexes to control branched actin network disassembly through oxidation of Met293.

A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing

The paper reports crystal and cryo-EM structures of zebrafish RET revealing conformational flexibility and strict geometric spacing in ligand-co-receptor recognition.

Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans

The paper identifies pre-existing and de novo humoral immunity to SARS-CoV-2 in humans, showing that uninfected individuals have SARS-CoV-2 S-reactive antibodies, particularly in children, and that infection leads to higher antibody titres targeting multiple subunits.

Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms

The paper determines cryo-EM structures of human Arp2/3 complexes with different ARPC5 isoforms to show how isoform variation affects complex activity.

Free ISG15 as a dimer generates IL-1β-producing CD8α+ dendritic cells at the site of infection

The paper shows free ISG15 dimers enhance IL-1β production by CD8+ dendritic cells during Toxoplasma infection, linking ISG15 to cytokine responses.