Chlorotoxin Redirects Chimeric Antigen Receptor T Cells for Specific and Effective Targeting of Glioblastoma
D. Wang, R. Starr, W.-C. Chang, B. Aguilar, D. Alizadeh, S. L. Wright, X. Yang, A. Brito, A. Sarkissian, J. R. Ostberg, Y. Shi, M. Gutova, K. Aboody, B. Badie, S. J. Forman, , C. Brown
This study develops a CAR T cell therapy using chlorotoxin to target glioblastoma with high specificity and potency, overcoming tumor heterogeneity challenges.
bioRxiv · Jan 24, 2020 · PreprintImmunology