Author

S. Laufer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Assay:flow cytometry· 1 Organism:mouse· 1

Frequent Co-Authors

A. Bayrak· 2 shared A.-K. Rohlfing· 2 shared D. Schaale· 2 shared M. Sigle· 2 shared T. Castor· 2 shared T. Pillaiyar· 2 shared V. Dicenta-Baunach· 2 shared Z. Laspa· 2 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersPhysiology

A. Bayrak

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ACKR3 agonism induces heterodimerization with chemokine receptor CXCR4 and attenuates platelet function

V. Dicenta-Baunach, Z. Laspa, D. Schaale, M. Sigle, A. Bayrak, T. Castor, T. Pillaiyar, S. Laufer, M. P. Gawaz, A.-K. Rohlfing

This study shows that ACKR3 agonism promotes heterodimerization with CXCR4 in platelets, reducing platelet activation and thrombus formation by modulating CXCR4 signaling.

European Journal of Clinical Investigation · Jan 1, 2025Peer-reviewedPhysiology

Hemin-induced platelet activation is regulated via ACKR3 chemokine surface receptor - implications for passivation of vulnerable atherosclerotic plaque

Z. Laspa, V. Dicenta-Baunach, D. Schaale, M. Sigle, R. Hochuli, T. Castor, A. Bayrak, T. Harm, K. A. L. Mueller, T. Pillaiyar, S. Laufer, A.-K. Rohlfing, M. Gawaz

This study shows hemin activates platelets and promotes thrombosis, which can be inhibited by ACKR3 agonists, suggesting a potential therapeutic strategy for atherosclerotic plaque vulnerability.

bioRxiv · May 13, 2024 · PreprintCell Biology

Mapping the S1 and S1 subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents

L. Cianni, C. Lemke, E. Gilberg, C. Feldmann, F. Rosini, F. d. R. Rocho, J. F. R. Ribeiro, D. Y. Tezuka, C. D. Lopes, S. de Albuquerque, J. Bajorath, A. Leitao, S. Laufer, M. Gütschow, C. A. Montanari

The paper designs and tests 26 dipeptidyl nitrile inhibitors against cysteine proteases to map their S1/S1' subsites and identify potential trypanocidal agents.

bioRxiv · Sep 8, 2019Biochemistry

Progress Towards a Public Chemogenomic Set for Protein Kinases and a Call for Contributions

D. H. Drewry, C. I. Wells, D. M. Andrews, R. Angell, H. Al-Ali, A. D. Axtman, S. J. Capuzzi, J. M. Elkins, P. Ettmayer, M. Frederiksen, O. Gileadi, N. Gray, A. Hooper, S. Knapp, S. Laufer, , T. M. Willson

The paper shares progress on a kinase chemogenomic set, releases inhibitor profiling data, and calls for community collaboration to complete the set.

bioRxiv · Jan 31, 2017Pharmacology & Toxicology