J. Deme

An interbacterial lipase toxin with an unprecedented reverse domain arrangement defines a new class of type VII secretion system effector

The paper identifies a new class of T7SS effector, TslA, with a reverse domain arrangement and describes its secretion mechanism and functional properties.

Molecular structure of the intact bacterial flagellar basal body

The paper presents the molecular structure of the Salmonella flagellar basal body using cryo-electron microscopy, revealing how 173 protein molecules assemble into a complex spanning two membranes and a cell wall.

Nonameric structures of the cytoplasmic domain of FlhA and SctV in the context of the full-length protein

The paper determines the structure of the nonameric cytoplasmic domains of FlhA and SctV using cryo-EM, revealing a conserved interaction stabilizing the ring assembly.

Molecular basis for B. pertussis interference with complement, coagulation, fibrinolytic and contact activation systems: The cryo-EM structure of the Vag8-C1 inhibitor complex

The paper determines the cryo-EM structure of the Vag8-C1-INH complex, revealing how Vag8 disrupts C1-INH function by sequestering its Reactive Centre Loop.

Structures of the stator complex that drives rotation of the bacterial flagellum

The paper presents structures of stator complexes from multiple bacterial species, revealing an asymmetric A5B2 subunit assembly and its role in coupling ion flow to generate mechanical work.

Structure of a proton-powered molecular motor that drives protein transport and gliding motility

This study determines the structure of a proton-driven motor in Bacteroidetes bacteria and identifies key residues involved in its function.

Structure of the bacterial flagellar rotor MS-ring: a minimum inventory/maximum diversity system

This study presents the structure of the Salmonella MS-ring, revealing symmetry variation that explains its role in flagellar function.

The flagellar substrate specificity switch protein FlhB assembles onto the extra-membrane export gate to regulate type three secretion

The paper determines the structure of the FlhB/SctU switch protein in the type three secretion system export gate and shows its role in regulating secretion specificity.

A novel inhibitor of complement C5 provides structural insights into activation

The paper identifies a novel inhibitor from tick saliva, determines its structure bound to complement C5, and reveals a new mechanism of C5 inhibition.

The structure of an injectisome export gate demonstratesconservation of architecture in the core export gatebetween flagellar and virulence type three secretionsystems

The paper presents the structure of a T3SS export gate complex from Shigella at 3.5 Å resolution, confirming structural conservation with the flagellar system.