This study investigates the dispersal and population structure of Aedes notoscriptus mosquitoes using genomic data, finding high mobility and low genetic structure, which challenges localized control strategies.

bioRxiv · Jan 18, 2022Ecology

DNA-dependent binding of nargenicin to DnaE1 inhibits replication in Mycobacterium tuberculosis

M. D. Chengalroyen, M. K. Mason, A. Borsellini, R. Tassoni, G. L. Abrahams, S. Lynch, Y.-M. Ahn, J. Ambler, K. Young, B. M. Crowley, D. B. Olsen, D. F. Warner, C. E. Barry, H. I. M. Boshoff, M. Lamers, V. Mizrahi

This study shows nargenicin binds to Mtb DnaE1 DNA-dependent polymerase, inhibiting replication and inducing DNA damage response in tuberculosis bacteria.

bioRxiv · Oct 27, 2021Microbiology

Cervicovaginal microbiome composition drives metabolic profiles in healthy pregnancy

A. Oliver, B. LaMere, C. Weihe, S. Wandro, K. Lindsay, P. Wadhwa, D. Mills, D. T. Pride, O. Fiehn, T. Northen, M. de Raad, H. Li, J. B. H. Martiny, S. Lynch, K. Whiteson

The paper investigates how cervicovaginal microbiome composition influences metabolic profiles in healthy pregnancies across trimesters and the first year of life.

bioRxiv · Nov 13, 2019Microbiology