Author

M. Lamers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:bacteria (other)· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Assay:DNA methylation· 1 Organism:E. coli· 1

Frequent Co-Authors

A. Borsellini· 2 shared D. F. Warner· 2 shared M. Botto· 2 shared V. Mizrahi· 2 shared A. Ramudzuli· 1 shared B. Haagmans· 1 shared B. M. Crowley· 1 shared B. Rockx· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

A. Borsellini

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A high-throughput exonuclease assay based on the fluorescent base analog 2-aminopurine

M. Botto, S. Murthy, M. Lamers

The paper introduces a high-throughput exonuclease assay using 2-aminopurine and identifies a novel inhibitor of Mycobacterium tuberculosis PHP-exonuclease.

bioRxiv · Sep 12, 2022 · PreprintBiochemistry

A four-point molecular handover during Okazaki maturation

M. Botto, A. Borsellini, M. Lamers

The paper reveals a four-point molecular handover mechanism during Okazaki fragment maturation in E. coli, showing how DNA polymerases, endonuclease, and ligase coordinate to remove RNA primers.

bioRxiv · Aug 2, 2022Biochemistry

The mycobacterial mutasome: composition and recruitment in live cells

S. Gessner, Z. A.-M. Martin, M. A. Reiche, J. Santos, N. Dhar, R. Dinkele, T. J. de Wet, A. Ramudzuli, S. Anoosheh, D. M. Lang, J. Aaron, T. L. Chew, J. Herrmann, R. Mueller, J. D. McKinney, , D. F. Warner

This study identifies the molecular composition and function of the mycobacterial mutasome, showing that the ImuB-{beta} clamp interaction is essential for mutagenic DNA repair in mycobacteria.

bioRxiv · Nov 16, 2021Microbiology

DNA-dependent binding of nargenicin to DnaE1 inhibits replication in Mycobacterium tuberculosis

M. D. Chengalroyen, M. K. Mason, A. Borsellini, R. Tassoni, G. L. Abrahams, S. Lynch, Y.-M. Ahn, J. Ambler, K. Young, B. M. Crowley, D. B. Olsen, D. F. Warner, C. E. Barry, H. I. M. Boshoff, M. Lamers, V. Mizrahi

This study shows nargenicin binds to Mtb DnaE1 DNA-dependent polymerase, inhibiting replication and inducing DNA damage response in tuberculosis bacteria.

bioRxiv · Oct 27, 2021Microbiology

Comparative Pathogenesis Of COVID-19, MERS And SARS In A Non-Human Primate Model

B. Rockx, T. Kuiken, S. Herfst, T. Bestebroer, M. Lamers, D. de Meulder, G. van Amerongen, J. van de Brand, N. Okba, D. Schipper, P. van Run, L. Leijten, E. Verschoor, B. Verstrepen, J. Langermans, , B. Haagmans

This study compares the pathogenesis of SARS-CoV-2, MERS-CoV, and SARS-CoV in non-human primates, showing SARS-CoV-2 causes a COVID-19-like disease with prolonged viral excretion without clinical signs.

bioRxiv · Mar 17, 2020Microbiology