Author

K. Young

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 4 Bioengineering· 2 Physiology· 2 Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 11 Research Focus:cell type annotation· 4 Research Focus:host-pathogen & immune response· 4 Assay:bulk RNA-seq· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2

Frequent Co-Authors

J. B. Stanton· 3 shared D. B. Olsen· 2 shared E. Eudy· 2 shared H. A. von Recum· 2 shared J. Trowbridge· 2 shared J. Zhang· 2 shared S. L. Butt· 2 shared A. A. Exner· 1 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

J. B. Stanton

Mutual co-authors in cluster

Author profile →

13 papers

Recent·Most cited

A narrow ratio of nucleic acid to SARS-CoV-2 N-protein enables phase separation

P. M. Laughlin, K. Young, J. C.-Y. Wang, G. Gonzalez-Gutierrez, A. Zlotnick

This study investigates how the ratio of nucleic acid to SARS-CoV-2 N-protein affects liquid-liquid phase separation (LLPS) and finds that a 1:1 ratio maximizes condensate formation.

bioRxiv · Apr 10, 2024Biochemistry

Piscichuviral encephalitis in marine and freshwater chelonians: first evidence of jingchuviral disease

W. Laovechprasit, K. Young, B. A. Stacy, S. B. Tillis, R. J. Ossiboff, J. A. Vann, K. Subramaniam, D. Agnew, J. Zhang, S. Whitaker, A. Walker, A. M. Orgill, L. N. Howell, D. J. Shaver, J. B. Stanton

This study identifies three novel chuviruses as the cause of lymphocytic meningoencephalomyelitis in three aquatic turtles, providing the first in situ evidence of chuviral pathogenicity in animals.

bioRxiv · Feb 24, 2023Pathology

Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2

K. Yin, M. J. Peluso, X. Luo, R. Thomas, M.-G. Shin, J. Neidleman, A. Andrew, K. Young, T. Ma, R. Hoh, K. Anglin, B. Huang, U. Argueta, M. Lopez, D. Valdivieso, , N. R. Roan

This study identifies T cell dysregulation, inflammation, and mis-coordinated adaptive immune responses in Long COVID patients compared to non-LC individuals.

bioRxiv · Feb 9, 2023Immunology

Conventional polymers may unintentionally refill in vivo with unassociated drugs

K. Young, A. B. Dogan, C. Hernandez, A. A. Exner, H. A. von Recum

This paper investigates the refilling capacity of PLGA implants, finding that even unmodified PLGA can refill with unassociated drugs, contrary to expectations.

bioRxiv · Mar 21, 2022 · PreprintBioengineering

Putative novel avian paramyxoviruses identified from wild bird surveillance (United States, 2016?2018) and retrospective analysis of APMV-2s and APMV-6s in GenBank

K. Young, J. Q. Stephens, R. L. Poulson, D. Stallknecht, K. M. Dimitrov, S. L. Butt, J. B. Stanton

This study identifies new avian paramyxovirus species from wild birds and GenBank data, highlighting limitations in current classification criteria.

bioRxiv · Nov 12, 2021Microbiology

DNA-dependent binding of nargenicin to DnaE1 inhibits replication in Mycobacterium tuberculosis

M. D. Chengalroyen, M. K. Mason, A. Borsellini, R. Tassoni, G. L. Abrahams, S. Lynch, Y.-M. Ahn, J. Ambler, K. Young, B. M. Crowley, D. B. Olsen, D. F. Warner, C. E. Barry, H. I. M. Boshoff, M. Lamers, V. Mizrahi

This study shows nargenicin binds to Mtb DnaE1 DNA-dependent polymerase, inhibiting replication and inducing DNA damage response in tuberculosis bacteria.

bioRxiv · Oct 27, 2021Microbiology

Effects of High-Volume versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations

C. Vann, C. Sexton, S. Osburn, M. Smith, C. Haun, M. Rumbley, P. Mumford, B. Ferguson, N. Montgomery, C. Fox, B. Ruple, J. McKendry, J. McLeod, A. Bashir, R. Beyers, , M. Roberts

This study compares high-volume and high-load resistance training on muscle growth and molecular markers, finding similar hypertrophic and strength adaptations despite differences in protein synthesis rates.

bioRxiv · Jul 1, 2021Physiology

Simple degradable cyclodextrin polyester with chelator-based crosslinker for stent-based drug delivery

K. Young, A. E. Lord, G. E. Burkhart, S. K. Kozawa, N. Mu, H. A. von Recum

This paper develops a cyclodextrin polyester with a chelator-based crosslinker for stent-based drug delivery, showing controlled drug release and stable coating on metal stents.

bioRxiv · Apr 29, 2021 · PreprintBioengineering

Antifibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis

G. Li, C. Lee, A. T. Read, K. Wang, I. Navarro, J. Cui, K. Young, R. Gorijavolu, T. Sulchek, C. Kopczynski, S. Farsiu, J. Samples, P. Challa, C. R. Ethier, W. D. Stamer

This study shows that netarsudil, a rho-kinase inhibitor, reverses glucocorticoid-induced ocular hypertension by reducing fibrosis and restoring outflow function.

bioRxiv · Jul 17, 2020Physiology

Heritable Genetic Background Alters Survival and Phenotype of Mll-AF9-Induced Leukemias

K. Young, M. Loberg, E. Eudy, L. Schwartz, K. Mujica, J. Trowbridge

This study shows that genetic background affects survival and leukemia phenotype in Mll-AF9-induced leukemias in mice.

bioRxiv · Jun 13, 2020Cancer Biology

Aging-Associated Decrease in the Histone Acetyltransferase KAT6B Causes Myeloid-Biased Hematopoietic Stem Cell Differentiation

E. S. Khokhar, S. Borikar, E. Eudy, T. Stearns, K. Young, J. Trowbridge

This study shows that aging reduces KAT6B, an epigenetic regulator, leading to myeloid-biased differentiation of hematopoietic stem cells.

bioRxiv · Jun 22, 2019Cell Biology

Real-time, MinION-based, amplicon sequencing for lineage typing of infectious bronchitis virus from upper respiratory samples

S. L. Butt, E. C. Erwood, J. Zhang, H. S. Sellers, K. Young, K. K. Lahmers, J. B. Stanton

This paper describes a MinION-based AmpSeq method for rapid and accurate lineage typing of infectious bronchitis virus from clinical samples, showing high detection accuracy in mixed isolates.

bioRxiv · May 10, 2019Microbiology

Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis

S. B. Singh, J. Odingo, M. A. Bailey, B. Sunde, A. Korkegian, T. O'Malley, Y. Ovechkina, T. R. Ioerger, J. C. Sacchettini, K. Young, D. B. Olsen, T. Parish

The paper screens 500 natural products for anti-tubercular activity, identifies five active cyclic hexapeptides, and shows structural analogs lack activity.

bioRxiv · Mar 10, 2018Microbiology