BiophysicsbioRxiv
Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin
M. H. Doran, M. J. Rynkiewicz, D. Rasicci…·W. Lehman
The paper uses cryo-EM to determine high-resolution structures of human cardiac myosin bound to actin-tropomyosin in the presence and absence of Mg2+·ADP, revealing conformational changes linked to ADP release and force-sensitivity.