Drug-induced adaptation along a resistance continuum in cancer cells
G. S. Franca, M. Baron, M. Pour, B. R. King, A. Rao, S. Misirlioglu, D. Barkley, I. Dolgalev, K. Ho-Tang, G. Avital, F. Kuperwaser, A. Patel, D. A. Levine, T. Lionnet, I. Yanai
This study shows that gradual dose exposure and prolonged treatment drive ovarian cancer cell resistance to targeted therapy through a continuous adaptation process involving transcriptional, epigenetic, and genetic changes.
bioRxiv · Jun 21, 2022Cancer Biology