Author

T. Lionnet

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 2 Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:chromatin & epigenetic regulation· 4 Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Assay:Hi-C· 2

Frequent Co-Authors

A. Tsirigos· 2 shared S. Nomikou· 2 shared Y. Fu· 2 shared A. Kloetgen· 1 shared A. Patel· 1 shared A. Rao· 1 shared A. S. Holehouse· 1 shared B. R. King· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

A. Tsirigos

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Connecting Chromatin Structures to Gene Regulation Using Dynamic Polymer Simulations

Y. Fu, T. Zhao, F. T. Clark, S. Nomikou, A. Tsirigos, T. Lionnet

The paper uses polymer simulations to model chromatin dynamics and shows that productive interactions depend on contact frequency, capture radius, and duration, not just average contact matrices.

bioRxiv · Nov 7, 2023 · PreprintBiophysics

Drug-induced adaptation along a resistance continuum in cancer cells

G. S. Franca, M. Baron, M. Pour, B. R. King, A. Rao, S. Misirlioglu, D. Barkley, I. Dolgalev, K. Ho-Tang, G. Avital, F. Kuperwaser, A. Patel, D. A. Levine, T. Lionnet, I. Yanai

This study shows that gradual dose exposure and prolonged treatment drive ovarian cancer cell resistance to targeted therapy through a continuous adaptation process involving transcriptional, epigenetic, and genetic changes.

bioRxiv · Jun 21, 2022Cancer Biology

The kinetic landscape of human transcription factors

N. E. Mamrak, N. Alerasool, D. Griffith, A. S. Holehouse, M. Taipale, T. Lionnet

This study develops CRISPRburst to measure how 92 human transcription factors affect transcriptional bursting kinetics and identifies kinetic signatures that classify TFs and predict their regulatory roles.

bioRxiv · Jun 1, 2022 · PreprintBiophysics

Dynamic 3D chromosomal landscapes in acute leukemia

A. Kloetgen, P. Thandapani, P. Ntziachristos, Y. Ghebrechristos, S. Nomikou, C. Lazaris, X. Chen, H. Hu, S. Bakogianni, J. Wang, Y. Fu, F. Boccalatte, H. Zhong, E. Paietta, T. Trimarchi, , A. Tsirigos

The paper examines 3D chromatin changes in T-ALL, identifies TAD fusion events linked to oncogene activation, and shows drug treatments can restore some interactions.

bioRxiv · Aug 4, 2019Cancer Biology

Quantitative measurements of chromatin modification dynamics during zygotic genome activation

Y. Sato, L. Hilbert, H. Oda, Y. Wan, J. M. Heddleston, T.-L. Chew, V. Zaburdaev, P. Keller, T. Lionnet, N. Vastenhouw, H. Kimura

The paper quantifies chromatin modification dynamics during zygotic genome activation in zebrafish embryos using fluorescent antibody imaging.

bioRxiv · Apr 6, 2019 · PreprintCell Biology