Cancer BiologybioRxiv
Most commonly mutated genes in High Grade Serous Ovarian Carcinoma are nonessential for ovarian surface epithelial stem cell transformation
R. J. Yamulla, S. Nalubola, A. Flesken-Nikitin…·J. C. Schimenti
This study identifies mutation combinations critical for ovarian surface epithelial stem cell transformation in HGSOC using CRISPR mutagenesis, showing most common mutations have no effect while RB1/PTEN/TP53 disruption is essential.
DOI 10.1016/j.celrep.2020.108086