Targeted Degradation of CDK9 Potently Disrupts the MYC Transcriptional Network
M. A. Toure, K. Motoyama, Y. Xiang, J. Urgiles, F. Kabinger, A.-S. Koglin, R. S. Iyer, K. Gagnon, A. Kumar, S. Ojeda, D. A. Harrison, M. G. Rees, J. A. Roth, C. J. Ott, R. Schiavoni, , A. N. Koehler
This study shows that CDK9 degradation with KI-CDK9d-32 is more effective than inhibition in disrupting MYC transcriptional networks and causes MYC downregulation and nucleolar destabilization.
bioRxiv · May 14, 2024 · PreprintCancer Biology