Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
7 papers
Recent·Most cited
W. Li, E. M. Garcia-Rivera, D. C. Mitchell, J. M. Chick, M. Maetani, J. M. Knapp, G. M. Matthews, R. Shirasaki, R. de Matos Simoes, V. Viswanathan, J. L. Pulice, M. G. Rees, J. A. Roth, S. P. Gygi, C. S. Mitsiades, , J. M. L. Ostrem
The paper identifies a small molecule, BRD1732, that is ubiquitinated in cells, leading to proteasome inhibition through accumulation of ubiquitin chains.
bioRxiv · Jan 26, 2024Biochemistry
U. N. Wasko, J. Jiang, A. C. Garcia, Y. Wang, B. Lee, M. Orlen, K. Drizyte-Miller, M. Menard, J. Dilly, S. A. Sastra, C. F. Palermo, T. Dalton, M. C. Hasselluhn, A. R. Decker-Farrell, S. Chang, , R. H Vonderheide
This study evaluates the therapeutic potential of RMC-7977, a broad-spectrum RAS inhibitor, in pancreatic ductal adenocarcinoma models, showing strong anti-tumor effects with minimal impact on normal tissues.
bioRxiv · Dec 3, 2023 · PreprintCancer Biology
K. L. Abbott, A. Ali, D. Casalena, B. T. Do, R. Ferreira, J. H. Cheah, C. K. Soule, A. Deik, T. Kunchok, D. R. Schmidt, S. Renner, S. E. Honeder, M. Wu, S. H. Chan, T. Tseyang, , M. G. Vander Heiden
The paper screens compounds targeting metabolism in serum-derived medium to identify differential responses in cancer cells, aiming to improve drug response prediction.
bioRxiv · Feb 25, 2023Cancer Biology
M. Fan, W. Lu, J. Che, N. P. Kwiatkowski, Y. Gao, H.-S. Seo, S. B. Ficarro, P. C. Gokhale, Y. Liu, E. A. Geffken, J. Lakhani, K. Song, M. Kuljanin, W. Ji, J. Jiang, , N. Gray
This paper develops a covalent inhibitor of the YAP-TEAD complex, demonstrating its ability to suppress Hippo signaling defects and inhibit cancer cell growth.
bioRxiv · May 10, 2022Cancer Biology
A. A. Jourdain, O. S. Skinner, A. Kawakami, R. P. Goodman, H. Shen, L. V. Kemeny, L. Joesch-Cohen, M. G. Rees, J. A. Roth, D. E. Fisher, V. K. Mootha
The paper identifies a pathway called uridinolysis that allows cells to use uridine and RNA-derived ribose to support glycolysis when glucose is limiting.
bioRxiv · Jun 10, 2021 · PreprintBiochemistry
N. Boehnke, J. P. Straehla, H. C. Safford, M. Kocak, M. G. Rees, M. Ronan, D. Rosenberg, C. H. Adelmann, R. R. Chivukula, N. Nabar, A. G. Berger, N. G. Lamson, J. H. Cheah, H. Li, J. A. Roth, , P. T. Hammond
The paper uses a pooled screening approach to identify genomic factors influencing nanoparticle-cell interactions and validates biomarkers for nanoparticle uptake.
bioRxiv · Apr 5, 2021 · PreprintBioengineering
S. M. Corsello, R. T. Nagari, R. D. Spangler, J. Rossen, M. Kocak, J. G. Bryan, R. Humeidi, D. Peck, X. Wu, A. A. Tang, V. M. Wang, S. A. Bender, E. Lemire, R. Narayan, P. Montgomery, , T. R. Golub
The paper identifies non-oncology drugs with anti-cancer activity across 578 cancer cell lines using PRISM, finding that many drugs selectively inhibit cancer cells based on molecular features.
bioRxiv · Aug 9, 2019Cancer Biology