Proteolytic Cleavage by Matriptase Exacerbating Kidney Injury: a Novel Therapeutic Target
S. Ozawa, M. Matsubayashi, H. Nanaura, M. Yanagita, K. Mori, K. Asanuma, N. Kajiwara, K. Hayashi, H. Ohashi, M. Kasahara, H. Yokoi, H. Kataoka, E. Mori, T. Nakagawa
This study identifies Matriptase cleavage of Podocin as a mechanism of podocyte injury in CKD, suggesting Matriptase inhibition as a therapeutic strategy.
bioRxiv · Nov 15, 2019 · PreprintBiochemistry