K. Mori

Structure-activity relationships of coumarin and its analogs and mechanistic insights into germination inhibition by coumarin

This study investigates coumarin's structure-activity relationships and its mechanism of germination inhibition in two plant species, identifying key structural features and gene targets.

UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins

This study shows UGGT1 reglucosylation competes with EDEM-mediated degradation of misfolded glycoproteins, influencing ER protein quality control.

NEDD4-binding protein 1 suppresses HBV replication by degrading HBV RNAs

This paper identifies N4BP1 as a host factor that suppresses HBV replication by degrading HBV RNAs, with its KH-like and RNase domains required for this effect.

Characterization and contribution of RPE senescence to Age-related macular degeneration in Tnfrsf10 knock out mice

This study investigates how RPE senescence contributes to AMD using TNFRSF10A silenced hRPE cells and Tnfrsf10 KO mice, showing increased p16 and p21 expression and metabolic changes.

The orientation of choroidal macrophage polarization significantly influences the development of myopia in murine models

This study shows that choroidal macrophage polarization direction affects myopia development in mice, with M1 macrophages promoting and M2 macrophages suppressing myopia.

Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker

This study develops ultrasensitive assays to detect ORF1p in plasma, showing its potential as a multi-cancer biomarker for early detection and monitoring.

Blue light promotes ascorbate synthesis by deactivating the PAS/LOV photoreceptor that inhibits GDP-L-galactose phosphorylase

The paper identifies a photoreceptor, PLP, that inhibits ascorbate biosynthesis by interacting with GGP, and shows blue light deactivates PLP to promote ascorbate synthesis in tomato.

Environment-mediated vertical transmission fostered uncoupled phylogenetic relationships between longicorn beetles and their symbionts

This study investigates the evolutionary relationship between longicorn beetles and their fungal symbionts, finding that their phylogenetic relationships are incongruent, suggesting vertical transmission is imperfect and diet influences mycetome retention.

Non-glycosylated Seipin to Cause a Motor Neuron Disease Induces ER stress and Apoptosis by Inactivating the ER Calcium Pump SERCA2b

Overexpression of the RNA-binding protein NrdA affects global gene expression and secondary metabolism in Aspergillus species

This study shows that overexpression of NrdA affects global gene expression and secondary metabolism in Aspergillus species, with specific impacts on metabolite production.

The ATF6β-calreticulin axis protects hippocampal neurons against endoplasmic reticulum stress and excitotoxicity

This study shows that ATF6β-calreticulin protects hippocampal neurons from ER stress and excitotoxicity by maintaining Ca2+ homeostasis.

SARS-CoV-2 Neutralizing Antibody Responses Are More Robust in Patients with Severe Disease

This study finds that patients with severe SARS-CoV-2 disease have higher antibody titers against viral proteins and neutralization capabilities compared to less severe cases.

Molecular interaction mechanism of a 14-3-3 protein with a phosphorylated peptide elucidated by enhanced conformational sampling

This paper uses enhanced conformational sampling to study the binding mechanism of a phosphorylated peptide to a 14-3-3 protein, identifying stable clusters and a phosphorylation-dependent binding process.

Iron acquisition system of Sphingobium sp. strain SYK-6, a degrader of lignin-derived aromatic compounds

This study identifies the iron acquisition system in Sphingobium sp. strain SYK-6, revealing key transporters and regulatory mechanisms involved in iron uptake under limited conditions.

Proteolytic Cleavage by Matriptase Exacerbating Kidney Injury: a Novel Therapeutic Target

This study identifies Matriptase cleavage of Podocin as a mechanism of podocyte injury in CKD, suggesting Matriptase inhibition as a therapeutic strategy.

LaeA controls citric acid production through regulation of a citrate exporter encoding cexA in Aspergillus luchuensis mut. kawachii

This study identifies LaeA's role in regulating citric acid production in A. kawachii by controlling cexA expression through histone methylation.