S. Koike

Amelioration of age-related cognitive decline and anxiety in mice by Centella asiatica extract varies by sex, dose and mode of administration.

This study shows that Centella asiatica extract improves age-related cognitive decline and anxiety in mice, but effects vary by sex, dose, and administration method.

Actin dynamics switches two distinct modes of endosomal fusion in yolk sac visceral endoderm cells

Organelle landscape analysis using a multi-parametric particle-based method

The paper introduces a multi-parametric particle-based method to analyze organelle landscapes, enabling visualization of heterogeneous organelle structures and transitional states using fluorescence microscopy and UMAP.

Comprehensive analysis of nasal IgA antibodies induced by intranasal administration of the SARS-CoV-2 spike protein

This study shows that multimeric secretory IgA from nasal mucosa provides effective protection against SARS-CoV-2, even when monomeric IgA is non-neutralizing.

Paracrine signaling by pancreatic delta cells determines the glycemic set point in mice

This study shows that pancreatic delta cells regulate the glycemic set point in mice by modulating beta cell insulin response through paracrine signaling.

Timing of fruiting rather than topography determines the direction of vertical seed dispersal by mammals and birds

The paper shows that the timing of fruiting, not topography, determines vertical seed dispersal direction by mammals and birds in central Japan.

Alternative hydrogen uptake pathways suppress methane production in ruminants

This study identifies alternative hydrogen uptake pathways in ruminants that reduce methane production by competing with methanogens for hydrogen.

Development of the Brief Personal Values Inventory for sense of values in the Japanese general population

The paper develops a shorter questionnaire, BPVI, to assess sense of values in Japanese adults, showing it aligns with Schwartz's value theory and is suitable for comparing values across age groups.