Polyphosphate initiates tau aggregation through intra- and intermolecular scaffolding
S. P. Wickramasinghe, J. Lempart, H. E. Merens, J. Murphy, U. Jakob, E. Rhoades
This study shows polyphosphate initiates tau aggregation by altering its conformation and enabling noncovalent cross-linking.
bioRxiv · Mar 25, 2019Biophysics