Multi-Omics Analysis of Fibroblasts from the Invasive Tumor Edge Reveals that Tumor-Stroma Crosstalk Induces O-glycosylation of the CDK4-pRB Axis
G. Bouchard, F. J. G. Marques, L. G. Karacosta, W. Zhang, A. Bermudez, N. M. Riley, L. C. Mehl, J. A. Benson, J. B. Shrager, C. R. Bertozzi, S. Pitteri, A. J. Giaccia, S. K. Plevritis
The paper analyzes multi-omics data from fibroblasts at the tumor edge and core to show O-glycosylation of the CDK4-pRB axis is induced by tumor-stroma crosstalk.
bioRxiv · May 28, 2021 · PreprintCancer Biology