MicrobiologybioRxiv
Targeted protein S-nitrosylation of ACE2 as potential treatment to prevent spread of SARS-CoV-2 infection
C.-k. Oh, T. Nakamura, N. Beutler…·S. A. Lipton
This paper develops aminoadamantane nitrate compounds that inhibit SARS-CoV-2 infection by S-nitrosylating ACE2 and blocking viral entry, showing efficacy in vitro and in a Syrian hamster model.
DOI 10.1038/s41589-022-01149-6