ImmunologybioRxiv
Effects of IL2/anti-IL2 antibody complex on chikungunya virus-induced arthritis in a mouse model
S. R. Tritsch, A. J. Porzucek, A. M. Schwartz…·A. Y. Chang
The paper tests the effects of IL2/anti-IL2 antibody complex and anti-IL2 mAb on CHIKV arthritis in mice, finding that the complex increases IL2 and Tregs but also Teffs, while the antibody reduces disease scores by increasing IL2 availability.
DOI 10.1038/s41598-023-34578-x