Structural heterogeneity of amyloid aggregates identified by spatially resolved nanoscale infrared spectroscopy
S. Banerjee, B. Holcombe, S. Ringold, A. Foes, A. Ghosh
This study uses AFM-IR to show structural heterogeneity in amyloid aggregates, revealing that fibrils can have structurally different domains and that early-stage aggregates exhibit varied conformations.
bioRxiv · May 7, 2022 · PreprintBiophysics