Large- and Small-Animal Studies of Safety, Pharmacokinetics (PK), and Biodistribution of Inflammasome-Targeting Nanoligomer in the Brain and Other Target Organs
S. Risen, B. Kusick, S. Sharma, V. Gilberto, S. Brindley, M. Aguilar, J. Brown, S. McGrath, A. Chatterjee, J. Moreno, P. Nagpal
This paper evaluates the safety, pharmacokinetics, and biodistribution of an inflammasome-targeting Nanoligomer cocktail in small and large animals across multiple administration routes.
bioRxiv · Feb 7, 2024Pharmacology & Toxicology