S. Robichaud

Foam cell induction activates AMPK but uncouples its regulation of autophagy and lysosomal homeostasis

This study shows that AMPK activation in foam cells disrupts lysosomal homeostasis despite maintaining basal AMPK signaling, suggesting a loss of AMPK's regulatory capacity in atherosclerosis.

Loss of MLKL Decreases Necrotic Core but Increases Macrophage Lipid Accumulation In Atherosclerosis

This study shows that reducing MLKL in atherosclerosis decreases necrotic cores but increases macrophage lipid accumulation, revealing a novel role for MLKL in lipid uptake.