M. Cote

Nanoparticles co-delivering siRNA and mRNA for simultaneous restoration and silencing of gene/protein expression in vitro and invivo

This study develops nanoparticles that co-deliver siRNA and mRNA to simultaneously silence and restore gene/protein expression in vitro and in vivo.

Delineating the functional activity of antibodies with cross-reactivity to SARS-CoV-2, SARS-CoV-1 and related sarbecoviruses

This study identifies cross-reactive antibodies against SARS-CoV-2 and related sarbecoviruses that target conserved epitopes and show broad neutralization potential.

Temperature-dependent Spike-ACE2 interaction of Omicron subvariants is associated with viral transmission

This study examines how temperature affects Spike-ACE2 interactions in Omicron subvariants and links these interactions to viral transmission efficiency.

An Integrated Optogenetic and Bioelectronic Platform for Regulating Cardiomyocyte Function

This paper introduces an integrated optogenetic and bioelectronic platform to modulate and monitor cardiomyocyte function in vitro, showing a 14% increase in beat rate with blue light stimulation.

Sphingosine kinases promote Ebola virus infection and can be targeted to inhibit filoviruses, coronaviruses, and arenaviruses using late endocytic trafficking to enter cells

This study shows that sphingosine kinases (SKs) facilitate entry of late-penetrating viruses like Ebola and SARS-CoV-2 by promoting endocytic trafficking, and their inhibition blocks viral entry.

Molecular basis for antiviral activity of pediatric neutralizing antibodies targeting SARS-CoV-2 Spike receptor binding domain

This study identifies two potent neutralizing antibodies, EH3 and EH8, from a pediatric patient that cross-neutralize SARS-CoV-2 variants and provide in vivo protection against the Delta VOC.

Highly divergent white-tailed deer SARS-CoV-2 with potential deer-to-human transmission

The paper identifies a highly divergent SARS-CoV-2 lineage in white-tailed deer with evidence of deer-to-human transmission.

Identification of a SARS-CoV-2 host metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 and variants of concern Alpha, Delta, and Omicron

This study identifies a MMP2/9-dependent entry pathway for SARS-CoV-2 and variants, showing differential usage and reduced activity in Omicron.

VE607 Stabilizes SARS-CoV-2 Spike In the "RBD-up" Conformation and Inhibits Viral Entry

VE607 inhibits SARS-CoV-2 infection by stabilizing the RBD in the 'up' conformation and blocking S-ACE2 interaction across multiple variants.

SARS-CoV-2 Omicron Spike recognition by plasma from individuals receiving BNT162b2 mRNA vaccination with a 16-weeks interval between doses

This study evaluates how plasma from individuals with a 16-week interval between BNT162b2 mRNA vaccine doses recognizes and neutralizes the Omicron Spike compared to other variants.

Contribution of single mutations to selected SARS-CoV-2 emerging variants Spike antigenicity

The paper evaluates how single mutations in SARS-CoV-2 Spike protein affect antigenicity and ACE2 binding in emerging variants.

Structural Basis and Mode of Action for Two Broadly Neutralizing Antibodies Against SARS-CoV-2 Emerging Variants of Concern

This study characterizes two SARS-CoV-2 antibodies effective against variants, showing their structural basis and mechanisms of neutralization.

Peptide Ancestry Informative Markers in Uterine Neoplasms from Women of European, African and Asian Ancestry

The paper identifies peptide ancestry informative markers (pAIMs) that correlate with ancestry in uterine neoplasms, showing they can accurately determine ancestry proportions with high precision.

Foam cell induction activates AMPK but uncouples its regulation of autophagy and lysosomal homeostasis

This study shows that AMPK activation in foam cells disrupts lysosomal homeostasis despite maintaining basal AMPK signaling, suggesting a loss of AMPK's regulatory capacity in atherosclerosis.

Cross-sectional evaluation of humoral responses against SARS-CoV-2 Spike

This study evaluates humoral responses against SARS-CoV-2 Spike in 106 infected individuals, finding persistent RBD-specific IgG and declining neutralizing activity over time.

Characterization of LXR-activating nanoparticle formulations in primary mouse macrophages

This study compares three nanoparticle formulations for delivering an LXR activator to mouse macrophages, finding that redox-sensitive formulations enhance ABCA1 protein expression.