Conformational switch of a peptide provides a novel strategy to design peptide loaded porous organic polymer for Pyroptosis pathway mediated cancer therapy
K. Chattopahyay, S. Mishra, A. Sannigrahi, S. Ruidas, S. Chatterjee, K. Roy, D. Mishra, B. K. Maity, R. Paul, K. Das Saha, A. Bhaumik
This paper designs a peptide-loaded porous organic polymer that undergoes a conformational switch in cancer cells, triggering pyroptosis via membrane pore formation.
bioRxiv · Mar 5, 2024Biochemistry