R. Paul

Confinement in fibrous environments positions and orients mitotic spindles

This study investigates how ECM-confinement affects mitotic spindle positioning and orientation through mechanical interactions and RF patterning.

Conformational switch of a peptide provides a novel strategy to design peptide loaded porous organic polymer for Pyroptosis pathway mediated cancer therapy

This paper designs a peptide-loaded porous organic polymer that undergoes a conformational switch in cancer cells, triggering pyroptosis via membrane pore formation.

Leishmania major-induced alteration of host cellular and systemic copper homeostasis drives the fate of infection

This study shows Leishmania major manipulates host copper homeostasis to evade immune responses, while macrophages use copper to kill parasites.

A mechanistic model for nuclear migration in hyphae during mitosis

The paper develops a mechanistic model explaining how nuclei migrate through hyphae during mitosis in fungi, showing that dynein activity on astral microtubules is critical for timely migration.

Microtubule search-and-capture model evaluates the effect of chromosomal volume conservation on spindle assembly during mitosis

Complex organic matter degradation by secondary consumers in chemolithoautotrophy-based subsurface geothermal ecosystems

The paper examines enzyme activity in geothermal ecosystems, finding that peptidases dominate over CAZymes, indicating reliance on bacterial biomass rather than plant matter for organic carbon.

Hydrodynamic dissection of single cells in a microfluidic system

This paper describes a microfluidic hydrodynamic splitter for non-contact splitting of Stentor coeruleus cells, showing that fragment size and mechanical stress affect viability and regeneration.

A force-balance model for centrosome positioning and spindle elongation during Interphase and Anaphase B

The paper develops a computational model to explain centrosome positioning and spindle elongation during interphase and anaphase B by simulating forces from astral microtubules and interpolar microtubules.

Redox state and cellular uptake of copper is regulated by the N-terminus of human Copper Transporter-1

The paper shows that the N-terminus of hCTR1 regulates copper uptake by coordinating Cu(I) and facilitating its reduction from Cu(II).

Mechanics of MTOC clustering and spindle positioning in budding yeast Cryptococcus neoformans

The paper investigates MTOC clustering and spindle positioning in Cryptococcus neoformans using a search and capture model and computational simulations.

The novel leishmanial Copper P-type ATPase plays a vital role in intracellular parasite survival

This study identifies and characterizes the Leishmania major Cu-ATPase, LmATP7, and demonstrates its role in copper stress resistance and parasite survival within macrophages.

Correlation and co-localization of QTL for stomatal density and canopy temperature under drought stress in Setaria

The paper identifies QTLs for stomatal density and canopy temperature in Setaria under drought stress, showing their genetic correlation and potential for improving water use efficiency.

Mechanics of multi-centrosomal clustering in bipolar mitotic spindles

This study computationally screens mechanical forces in multi-centrosomal cells to determine conditions for bipolar spindle assembly and identifies configurations for abnormal spindles.

Hepatitis E as a cause of adult hospitalization in Bangladesh: Results from an acute jaundice surveillance study in six tertiary hospitals, 2014-2017

This study estimates the burden of hepatitis E virus (HEV) in Bangladesh by analyzing acute jaundice hospitalizations, finding HEV as the leading cause with significant mortality and geographic patterns.