Author

S. Sakuraba

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

H. Kono· 2 shared K. Kasahara· 2 shared A. Kumar· 1 shared A. Machiyama· 1 shared A. Oguni· 1 shared B. Ma· 1 shared C. Okada· 1 shared G.-J. Bekker· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

H. Kono

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Fly-casting with ligand-sliding and orientational selection to support the complex formation of a GPCR and a middle-sized flexible molecule

J. Higo, K. Kasahara, G.-J. Bekker, B. Ma, S. Sakuraba, S. Iida, N. Kamiya, I. Fukuda, H. Kono, Y. Fukunishi, H. Nakamura

This paper uses a computational method to simulate the binding mechanism of bosentan to hETB, identifying key steps like fly-casting and ligand-sliding.

bioRxiv · Feb 28, 2022 · PreprintBiophysics

Structural basis of the regulation of normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2

K. Sato, A. Kumar, K. Hamada, C. Okada, A. Oguni, A. Machiyama, S. Sakuraba, T. Nishizawa, O. Nureki, H. Kono, K. Ogata, T. Sengoku

This study determines the cryo-EM structure of NSD2 bound to a nucleosome and identifies oncogenic mutations that increase its catalytic activity by altering the autoinhibitory loop conformation.

Nature Communications · Nov 15, 2021Peer-reviewedBiochemistry

Modeling the SARS-CoV-2 nsp1--5'-UTR complex via extended ensemble simulations

S. Sakuraba, X. Qilin, K. Kasahara

This study uses molecular dynamics simulations to investigate how SARS-CoV-2 RNA evades nsp1-mediated host translation shutoff by interacting with specific regions of nsp1.

bioRxiv · Feb 24, 2021Biophysics