S. Iida

Orientation-Independent-DIC imaging reveals that a transient rise in depletion force contributes to mitotic chromosome condensation

The paper uses OI-DIC imaging to show that a transient increase in depletion force, caused by macromolecular crowding, contributes to mitotic chromosome condensation in human cells.

Combination therapy with oral antiviral and anti-inflammatory drugs improves the efficacy of delayed treatment in severe COVID-19

This study shows that combining an oral antiviral with a corticosteroid improves treatment outcomes in delayed SARS-CoV-2 infection in hamsters compared to monotherapy.

Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates

This study evaluates the replicative ability and pathogenicity of SARS-CoV-2 BA.2.75 isolates in Syrian hamsters, finding higher lung replication and focal pneumonia compared to BA.2 and BA.5.

Intranasal vaccination induced cross-protective secretory IgA antibodies against SARS-CoV-2 variants with reducing the potential risk of lung eosinophilic immunopathology

This study shows that an intranasal vaccine with CpG ODN2006 induces secretory IgA antibodies against SARS-CoV-2 variants and reduces lung eosinophilic immunopathology compared to subcutaneous vaccination.

Fly-casting with ligand-sliding and orientational selection to support the complex formation of a GPCR and a middle-sized flexible molecule

This paper uses a computational method to simulate the binding mechanism of bosentan to hETB, identifying key steps like fly-casting and ligand-sliding.

Oral administration of S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and accelerates recovery from clinical aspects of COVID-19

This study shows that oral S-217622 reduces SARS-CoV-2 viral load and improves recovery in hamsters, with activity against multiple variants.

Subacute SARS-CoV-2 replication can be controlled in the absence of CD8+ T cells in cynomolgus macaques

This study shows that subacute SARS-CoV-2 replication can be controlled without CD8+ T cells in cynomolgus macaques, suggesting CD8+ T-cell dysfunction may not solely cause viral control failure.

The peripheral T cell population is associated with pneumonia severity in cynomolgus monkeys experimentally infected with severe acute respiratory syndrome coronavirus 2

This study shows that cynomolgus monkeys with lower peripheral T cell counts experience more severe pneumonia after SARS-CoV-2 infection compared to those with higher T cell counts.

Suberoyl bis-hydroxamic acid reactivates Kaposis sarcoma-associated herpesvirus through histone acetylation and induces apoptosis in lymphoma cells

This paper shows that SBHA reactivates KSHV in PEL cells through histone acetylation and induces apoptosis via the mitochondrial pathway, suggesting its potential as a therapeutic for PEL.