T. Nishizawa

The paper determines the cryo-EM structure of the human Bre1 complex bound to the nucleosome, revealing how it catalyzes H2B monoubiquitination and its potential role in cancer.

This study determines the cryo-EM structure of NSD2 bound to a nucleosome and identifies oncogenic mutations that increase its catalytic activity by altering the autoinhibitory loop conformation.

The paper identifies the biosynthesis pathway of asparaptine A using metabolome network analysis and shows its blood pressure-lowering effects in mice.

Cryo-EM structures of SERCA2b reveal how the luminal extension tail regulates its activity by controlling conformational transitions between states.

The paper reports cryo-EM structures of six intermediates in the ATP8A1-CDC50a flippase cycle, revealing the mechanism of phospholipid translocation.

This paper reports the cryo-EM structure of the human LAT1-CD98hc heterodimer, revealing its architecture and interactions, and maps disease mutations to explain congenital disorders.

This study determines the crystal structures of TPT bound to substrates, revealing the molecular basis of its strict 1:1 exchange mechanism.