Pharmacology & ToxicologybioRxiv
Effector membrane translocation biosensors reveal G protein and β-arrestin coupling profiles of 100 therapeutically relevant GPCRs
C. Avet, A. Mancini, B. Breton…·M. Bouvier
The paper develops EMTA biosensors to profile G protein and β-arrestin coupling of 100 GPCRs, revealing diverse signaling profiles and drug-target interactions.
DOI 10.7554/elife.74101