CRISPR-Cas provides limited phage immunity to a prevalent gut bacterium in gnotobiotic mice
T. S. Rasmussen, A. K. Koefoed, L. Deng, M. K. Muhammed, G. M. Rousseau, W. P. Kot, S. Sprotte, H. Neve, C. M. A. P. Franz, A. K. Hansen, F. K. Vogensen, S. Moineau, D. S. Nielsen
This study shows that the CRISPR-Cas system of Eggerthella lenta provides limited phage immunity in vitro and in vivo, allowing coexistence of phage and bacteria in the gut.
bioRxiv · May 20, 2022Microbiology