D. S. Nielsen

This study investigates how early life factors influence the gut virome composition in infants, identifying environmental exposures that shape viral communities and their potential metabolic impacts.

This study develops modified fecal virome transplants (FVT) to reduce donor variability and infection risks in treating C. difficile infections, showing improved efficacy and safety in a mouse model.

The paper investigates how the choice of ultrafilter affects the recovery of bacteriophages from clinical samples, finding that pore size influences recovery strain- and sample-dependently.

This study examines how colonic pH affects gut microbial composition and metabolite production using prebiotics in an in vitro setup, finding that higher pH promotes SCFA production.

Modified fecal virome transplantation improves blood glucose regulation in obese mice without reducing weight gain, while unmodified FVT reduces immune cell proportions in adipose tissue.

This study shows that continuous chemostat cultures reduce eukaryotic viruses in fecal material, suggesting a safer alternative to fecal microbiota transplantation.

This study shows that high levels of non-starch polysaccharides in diet impair type-2 immunity and increase susceptibility to enteric helminth infections in mice.

This study shows that fecal virome transplantation increases Akkermansia muciniphila abundance in mice and unexpectedly raises fertility rates in co-housed pairs.

This study shows that the CRISPR-Cas system of Eggerthella lenta provides limited phage immunity in vitro and in vivo, allowing coexistence of phage and bacteria in the gut.

This study shows that dietary proanthocyanidins enhance intestinal immune and antioxidant responses but have limited effects on pulmonary type-2 inflammation during Ascaris suum infection in pigs.

This study examines how probiotic mixtures affect helminth infection and gut microbiota in pigs, finding that BBE modulates type-2 inflammation and microbiota but not infection levels.

This study manually resolves viral dark matter in a large infant gut virome dataset, identifying over ten thousand viral species across 248 families and expanding bacteriophage taxonomy.

This study identifies prophages in infant gut metagenomes, showing they are largely induced and may influence microbiome dynamics through functional elements.

This study shows that cinnamaldehyde reduces intestinal inflammation and improves resistance to enteric parasite infection in mice, independent of gut microbiota.

This study shows a bacteriophage cocktail (FOP) reduces Listeria monocytogenes in simulated gut conditions without harming commensal bacteria, outperforming ampicillin in some aspects.

This study shows that a lacto-fermented rapeseed-seaweed blend improves gut health and microbiota composition in weaner piglets, with no additional benefit from increasing the blend's dietary inclusion beyond 2.5%.

This study shows that fecal filtrate transfer prevents necrotizing enterocolitis in preterm pigs without side effects, while fecal microbiota transplantation does not.

This study links gut mycobiome dysbiosis to hypertriglyceridemia in elderly Danes by analyzing dietary intake, fungal composition, and metabolomic data.

This study shows that faecal virome transplantation from lean donors reduces weight gain and improves glucose tolerance in obese mice, suggesting a role for gut viruses in metabolic health.

The paper links physical fitness in older adults to dietary intake, gut microbiota, and metabolomic signatures, identifying key factors explaining individual variation in fitness.

This study characterizes the vaginal DNA virome in patients with non-female factor infertility and finds associations between viral community composition and bacterial dysbiosis.

The paper isolates and characterizes a novel bacterium from an obese mouse's caecum, proposing a new genus and species based on genomic and phenotypic data.

This study shows that housing mice at thermoneutral temperatures reduces exercise training benefits in metabolic parameters and tissue adaptations.

This study shows that differences between mouse vendors have a greater impact on gut bacterial and viral communities than diet.

The paper develops a low-volume in vitro model of the small intestine (TSI) to study probiotic survival, showing that ileal microbiota significantly impacts probiotic survival.