Author

S. Moineau

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Evolutionary Biology· 2 Ecology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 8 Approach:experimental assay· 6 Organism:bacteria (other)· 5 Approach:statistical model· 5 Assay:metagenomics· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Nicot· 3 shared D. S. Nielsen· 3 shared L. Deng· 3 shared M. B. Dion· 3 shared M.-A. Petit· 3 shared S. Gandon· 3 shared F. Gatchitch· 2 shared G. M. Rousseau· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersEvolutionary Biology

A. Nicot

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Dairy practices select for thermostable endolysins in phages

F. Oechslin, X. Zhu, C. Morency, V. Somerville, R. Shi, S. Moineau

The paper shows that dairy practices have selected for thermostable endolysins in phages infecting Streptococcus thermophilus, reducing endolysin diversity.

bioRxiv · Sep 27, 2023 · PreprintMicrobiology

The influence of early life exposures on the infant gut virome

Y. Zhang, J. L. Castro-Mejia, L. Deng, S. A. Shah, J. Thorsen, C. L. Rodriguez, L. E. Jessen, M. B. Dion, B. Chawes, K. Bonnelykke, S. J. Sorensen, H. Bisgaard, S. Moineau, M.-A. Petit, J. Stokholm, D. S. Nielsen

This study investigates how early life factors influence the gut virome composition in infants, identifying environmental exposures that shape viral communities and their potential metabolic impacts.

bioRxiv · Mar 5, 2023Microbiology

Building pyramids against the evolutionary emergence of pathogens

S. Gandon, M. Guillemet, F. Gatchitch, A. Nicot, A. C. Renaud, D. M. Tremblay, S. Moineau

The paper compares three host resistance strategies to prevent pathogen evolutionary emergence, finding that pyramiding multiple defenses is more effective than mixing or combining strategies.

bioRxiv · Jul 7, 2022 · PreprintEvolutionary Biology

New Vista into Origins of Viruses from a Prototypic ssDNA Phage

N. Kejzar, E. Laanto, I. Rissanen, V. Abrishami, M. Selvaraj, S. Moineau, J. Ravantti, L.-R. Sundberg, J. T. Huiskonen

The paper characterizes a lipid-containing ssDNA phage, {Phi}CjT23, and suggests it represents a model for the last common ancestor of ssDNA and dsDNA viruses in the Bamfordvirae.

bioRxiv · May 27, 2022 · PreprintMicrobiology

CRISPR-Cas provides limited phage immunity to a prevalent gut bacterium in gnotobiotic mice

T. S. Rasmussen, A. K. Koefoed, L. Deng, M. K. Muhammed, G. M. Rousseau, W. P. Kot, S. Sprotte, H. Neve, C. M. A. P. Franz, A. K. Hansen, F. K. Vogensen, S. Moineau, D. S. Nielsen

This study shows that the CRISPR-Cas system of Eggerthella lenta provides limited phage immunity in vitro and in vivo, allowing coexistence of phage and bacteria in the gut.

bioRxiv · May 20, 2022Microbiology

Competition and coevolution drive the evolution and the diversification of CRISPR immunity

M. Guillemet, H. Chabas, A. Nicot, F. Gatchitch, E. Ortega-Abboud, C. Buus, L. Hindhede, G. M. Rousseau, T. Bataillon, S. Moineau, S. Gandon

This study shows coevolution between phages and bacteria drives CRISPR immunity diversification through negative-frequency-dependent selection and competitive asymmetries among host genotypes.

bioRxiv · Nov 12, 2021Microbiology

Hundreds of viral families in the healthy infant gut

S. A. Shah, L. Deng, J. Thorsen, A. G. Pedersen, M. B. Dion, J. Castro Mejia, R. Silins, F. O. Romme, R. Sausset, E. O. Ndela, M. H. Hjemso, M. A. Rasmussen, T. Redgwell, G. A. Vestergaard, Y. Zhang, , D. S. Nielsen

This study manually resolves viral dark matter in a large infant gut virome dataset, identifying over ten thousand viral species across 248 families and expanding bacteriophage taxonomy.

bioRxiv · Jul 2, 2021 · PreprintMicrobiology

Analysis of viromes and microbiomes from pig fecal samples reveals that phages and prophages are not vectors of antibiotic resistance genes

M. Billaud, Q. Lamy-Besnier, J. Lossouarn, E. Moncaut, M. B. Dion, S. Moineau, F. Traore, E. Le Chatelier, C. Denis, J. Estelle, C. Achard, O. Zemb, M.-A. Petit

The paper analyzes viromes and microbiomes from pig fecal samples to determine if phages or prophages carry antibiotic resistance genes, finding that ARGs are absent from active phages but present in prophages not detected in viromes.

bioRxiv · May 20, 2021Microbiology

Evolutionary emergence of infectious diseases in heterogeneous host populations

H. Chabas, S. Lion, A. Nicot, S. Meaden, S. van Houte, S. Moineau, L. M. Wahl, E. R. Westra, S. Gandon

This paper develops a theoretical model to predict pathogen emergence based on host population heterogeneity and validates it with experiments using bacteriophages and CRISPR-resistant bacteria.

bioRxiv · May 9, 2018Evolutionary Biology

Immune Loss as a Driver of Coexistence During Host-Phage Coevolution

J. L. Weissman, R. Holmes, R. Barrangou, S. Moineau, W. F. Fagan, B. R. Levin, P. L. Johnson

The paper shows that immune loss in bacteria can lead to stable coexistence with phages, contrasting with fitness tradeoffs, through theoretical and experimental analysis of CRISPR-Cas systems.

bioRxiv · Sep 18, 2017Ecology