Author

S. Stefanic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. C. W. Pike· 1 shared A. Kosturanova· 1 shared A. Pautsch· 1 shared A. Quigley· 1 shared B. Khanppnavar· 1 shared C. A. J. Hutter· 1 shared C. S. Tautermann· 1 shared D. B. Sauer· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperBiochemistry

A. C. W. Pike

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3 papers

Recent·Most cited

Structural basis of the mechanism and inhibition of a human ceramide synthase

T. C. Pascoa, A. C. W. Pike, C. S. Tautermann, G. Chi, M. Traub, A. Quigley, R. Chalk, S. Stefanic, S. Thamm, A. Pautsch, E. P. Carpenter, G. Schnapp, D. B. Sauer

This study determines the structural mechanism of CerS6, a ceramide synthase, using cryo-EM and biochemical analysis, revealing a ping-pong reaction mechanism and insights into fumonisin B1 inhibition.

bioRxiv · Dec 2, 2023Biochemistry

Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases

V. Mehta, B. Khanppnavar, D. Schuster, I. Kantarci, I. Vercellino, A. Kosturanova, T. Iype, S. Stefanic, P. Picotti, V. M. Korkhov

The paper determines the cryo-EM structure of Mycobacterium tuberculosis Cya, revealing its TM domain's role in catalytic activity regulation.

bioRxiv · Dec 1, 2021Biochemistry

The extracellular gate shapes the energy profile of an ABC exporter

C. A. J. Hutter, M. H. Timachi, L. M. Hürlimann, I. Zimmermann, P. Egloff, H. Göddeke, S. Kucher, S. Stefanic, M. Karttunen, L. V. Schäfer, E. Bordignon, M. A. Seeger

This study uses a synthetic antibody to determine the structure and mechanism of an ABC exporter's extracellular gate, showing its role in ATPase activity and transport.

bioRxiv · Sep 18, 2018Biochemistry