S. Thutupalli

Constrained dynamics of oligonucleotides in the phase-separated droplets

This study uses FCS to measure oligonucleotide dynamics in phase-separated droplets, showing spatial restriction significantly impacts diffusion.

Multispecies autocatalytic RNA reaction networks in coacervates

This study demonstrates the self-reproduction of an RNA system within coacervates, showing catalytic assembly and cross-catalytic activity in multispecies networks, leading to compositional identity and protection against perturbations.

Rethinking Population Bottlenecks: Intrinsic Fluctuations, Mutation and Dynamical Demographic Phases

The paper challenges the traditional view of population bottlenecks by showing that faster recovery can lead to fixation in different attractors depending on mutation rates.

GTPase-dependent cyclic flexibility transitions drive the two-component EEA1-Rab5 molecular motor

This study shows that Rab5 and EEA1 form a two-component molecular motor using GTP hydrolysis to drive cyclic flexibility transitions that perform mechanical work.

THE IMPACT OF MISTRANSLATION ON PHENOTYPIC VARIABILITY AND FITNESS

This study shows mistranslation increases phenotypic variation in E. coli cells but not across replicate populations, and provides a survival benefit under stress.