Author

J. Lauer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Animal Behavior & Cognition· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:clustering· 2 Approach:deep learning· 2 Organism:human· 2 Assay:imaging· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. Zerial· 4 shared A. Cezanne· 2 shared A. Mathis· 1 shared A. N. Lupas· 1 shared A. Singh· 1 shared A. Solomatina· 1 shared B. U. Klink· 1 shared C. Dulac· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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4 shared papersBiophysics

M. Zerial

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Video-driven simulation of lower limb mechanical loading during aquatic exercises

J. Lauer

This paper uses video-driven simulations to predict lower limb mechanical loading during aquatic exercises, showing agreement with in vivo measurements.

bioRxiv · Nov 23, 2022Bioengineering

GTPase-dependent cyclic flexibility transitions drive the two-component EEA1-Rab5 molecular motor

A. Singh, J. A. Soler, J. Lauer, S. W. Grill, M. Jahnel, M. Zerial, S. Thutupalli

This study shows that Rab5 and EEA1 form a two-component molecular motor using GTP hydrolysis to drive cyclic flexibility transitions that perform mechanical work.

bioRxiv · Jul 18, 2022 · PreprintBiophysics

Structure of the human FERRY Rab5 effector complex

D. Quentin, J. Schuhmacher, B. U. Klink, J. Lauer, T. Shaikh, P. J. Huis in 't Veld, L. M. Welp, H. Urlaub, M. Zerial, S. Raunser

The paper determines the cryo-EM structure of the human FERRY Rab5 effector complex and shows Fy-2 acts as a binding hub for subunits and mRNA/Rab5.

bioRxiv · Jun 21, 2021 · PreprintBiochemistry

Multi-animal pose estimation and tracking with DeepLabCut

J. Lauer, M. Zhou, S. Ye, W. Menegas, T. Nath, M. M. Rahman, V. Di Santo, D. Soberanes, G. Feng, V. N. Murthy, G. Lauder, C. Dulac, M. W. Mathis, A. Mathis

The paper enhances DeepLabCut for multi-animal pose estimation and tracking by adding identity prediction and robust assembly features, validated on four benchmark datasets.

bioRxiv · Apr 30, 2021Animal Behavior & Cognition

A non-linear system patterns Rab5 GTPase on the membrane

A. Cezanne, J. Lauer, A. Solomatina, I. F. Sbalzarini, M. Zerial

The paper demonstrates that Rab5 GTPase forms membrane patterns through a handover mechanism involving Rabex5/Rabaptin5 and requires an endosomal lipid composition.

bioRxiv · Dec 17, 2019Biochemistry

Allosteric structural alterations and auto-regulation of Rab5 GEF activity in Rabex5

J. Lauer, A. Cezanne, G. Guaitoli, F. Raimondi, M. Gentzel, V. Alva, M. Habeck, M. Ueffing, A. N. Lupas, C. J. Gloeckner, M. Zerial

This study reevaluates the autoinhibition mechanism of Rabex5 by analyzing structural changes and nucleotide exchange activity, revealing new regulatory roles for Ubiquitin binding domains.

bioRxiv · Feb 27, 2019 · PreprintBiophysics