MEK1/2 inhibition transiently alters the tumor immune microenvironment to enhance immunotherapy efficacy against head and neck cancer
M. Prasad, J. Zorea, S. Jagadeeshan, A. Shnerb, J. Bouaoud, L. Michon, O. Novoplansky, M. Badarni, L. Cohen, K. Yagodayev, S. Tzadok, B. Rotblat, L. Brezina, A. Mock, A. Karabajakian, , M. Elkabets
This study shows that MEK1/2 inhibition temporarily improves the tumor immune microenvironment, enhancing immunotherapy effectiveness in head and neck cancer by reducing suppressive myeloid cells and boosting CD8+ T cell activity.
Journal for ImmunoTherapy of Cancer · Mar 15, 2022Peer-reviewedCancer Biology